Cub domain-containing protein

WebJul 15, 2024 · This study advances CUB domain-containing protein 1 (CDCP1) as a novel target for metastatic castration-resistant prostate cancer, in both adenocarcinoma and neuroendocrine subtypes. Combined with low expression in normal human tissues, these data provide a compelling scientific rationale for translating CDCP1-directed RLT into the … CUB domain is an evolutionarily conserved protein domain. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guida…

Roles of CUB domain‐containing protein 1 signaling in cancer …

WebFeb 15, 2024 · CUB domain containing protein 1 (CDCP1), also known as Trask, gp140, SIMA135, and CD318, is a type I single-pass membrane protein that is highly overexpressed in a variety of solid tumors (12 – 14). WebOct 1, 2024 · CUB domain-containing protein 1 (CDCP1) is one of the few transmembrane glycoprotein that contains three extracellular CUB domains and … ray nicholson obituary https://otterfreak.com

CUB Domain–Containing Protein 1, a Prognostic Factor for Human ...

WebCUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner. WebDec 13, 2024 · Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ... XM_047418383.1 → XP_047274339.1 signal peptide, CUB and EGF-like domain-containing protein 3 isoform X4. XM_047418382.1 → XP_047274338.1 signal peptide, CUB and EGF-like domain … WebMar 29, 2024 · CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix … ray nicholson actor mother

CUB-domain–containing protein 1 (CDCP1) activates Src to …

Category:CUB-domain–containing protein 1 (CDCP1) activates Src to …

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Cub domain-containing protein

CUB domain - Wikipedia

WebSep 1, 2009 · CUB and sushi domain-containing protein 3. Alternative names. CUB and sushi multiple domains protein 3; Gene names. Name. CSMD3. Synonyms. KIAA1894. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. WebSummary. This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis.

Cub domain-containing protein

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WebFeb 15, 2024 · Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) could enable more effective … WebDec 3, 2012 · Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1 (CDCP1), by plasmin-like serine proteases induces outside–in signal transduction that facilitates early stages of ...

WebThe appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These domains are found in … WebAbstact. To measure the levels of serum CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in patients with ovarian cancer (OvCa), benign gynecological …

WebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two … WebOct 31, 2006 · PTHR24046:SF4 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1 1 hit; PROSITE. View protein in PROSITE; PS00010 ASX_HYDROXYL 6 hits; PS01180 CUB 1 hit; PS01186 EGF_2 6 hits; PS50026 EGF_3 6 hits; PS01187 EGF_CA 6 hits; Pfam. View protein in Pfam; PF12662 cEGF 1 hit; …

WebMay 5, 2024 · We here demonstrate that the CUB-like-domain containing protein RBT-1 acts as a functional receptor of Cry6A, which mediates the intestinal cell interaction and …

WebAug 1, 2009 · The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells … ray nicholson girlfriend 2021WebOct 3, 2024 · Abstract. Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein … ray nicholson promising young womanWebJul 27, 2011 · CUB and sushi domain-containing protein 1. Gene. Csmd1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Mus musculus (Mouse) Amino acids. 3564. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. Feature viewer. Publications. External links. History. BLAST Align. Download. Add Add a publication … simplisafe robert larson actorWebMar 2, 2015 · The transmembrane glycoprotein, CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein 1 (CDCP1) is overexpressed in several cancer types and is a predictor of poor … raynich stay with meWebNational Center for Biotechnology Information ray nicholson dating 2021WebOct 1, 2024 · CUB domain-containing protein 1 (CDCP1) is a transmembrane glycoprotein that contains three extracellular CUB domains and regulates anchorage … ray nichtingWebMay 5, 2024 · elegans CUB-like-domain containing protein RBT-1, released by phosphatidylinositol-specific phospholipase C (PI-PLC), was identified as a Cry6Aa binding protein by affinity chromatography. RBT-1 contained a predicted glycosylphosphatidylinositol (GPI) anchor site and was shown to locate in lipid rafts in the … raynic sports camera